Cannabis was prominent in 19th Century medicine and remained in the official US Pharmacopoeia 1850 until 1942, five years after its prohibition. Over 100 scientific papers were published on its use during this period, many about treating conditions for which its use has been confirmed today.
There were at least 2000 cannabis medicines produced by over 280 manufacturers over those decades. Various factors contributed to decreasing medical use at that time, but a smear and demonization campaign organized by various powerful interest groups is what led to federal criminalization.
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See full article – Cannabis History