In 1990, a researcher at University of North Carolina looked into how much THC is lost in combustion, and how much is lost as the cannabis joint smolders between puffs. He found 23-30% is burned up in the combustion process, while another 40-50% literally goes “up in smoke” between puffs. According to this study, as much as 80% of available THC never makes it to the patient.
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