Tolerance and reverse tolerance in cannabis medicine: When is “more less” and “less more” for various cannabinoids and individuals”…??

We’ve talked about how the human endocannabinoid system (ECS) is a “homeostatic” mechanism which works to keep bodily systems in balance. And it turns out, that as it’s receiving various doses of various phytocannabinoids it can do things as amazing as temporarily cutting down the number of some kinds of receptors if it has all that the system needs.

E.g., if someone is regularly, say, taking THC for personal use, and the body says “I don’t need any more of that, thanks” for optimum bodily health and balance, it can actually shut down receptors, meaning it takes more THC to get the same effect.

And then, equally impressively, if the person quits ingesting THC it can later increase the number of THC-sensitive receptors, indicating it’s ready and willing for more. This is homeostasis on a cellular level…!

There are differing receptivity considerations for different cannabinoids like CBD, THC-A, CBN, with some showing no positive tolerance effects.

There are also even “reverse tolerance” effects where the body over time needs less and less of a given cannabinoid to achieve a physiological effect. While CBD shows no evidence of tolerance, patients may develop a degree of sensitivity (reverse tolerance) such that they need lower doses to achieve the original effect (e.g., in controlling childhood epilepsy).

This interesting article explores these effects in some detail, our emerging knowledge about them, how they can effect a course of treatment.

#MMJ #Research #Tolerance #ReverseTolerance #UTpol #TRUCE [8/2017]    

See full article – Know Your Medicine: Tolerance and Reverse Tolerance